Actively Recruiting
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors
Led by M.D. Anderson Cancer Center · Updated on 2025-11-14
425
Participants Needed
1
Research Sites
676 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase IV trial studies how well serial magnetic resonance imaging (MRI) after radiation therapy works in predicting radiation-induced changes in the normal tissue of patients with oral cavity or skull base tumors. Performing MRIs after radiation therapy for patients with oral cavity or skull base tumors may help to predict osteoradionecrosis (a change in non-cancerous tissue).
CONDITIONS
Official Title
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years of age
- Patients with good performance status (ECOG score 0-2)
- Patients willing to give written informed consent
- Patients with histologically proven malignant neoplasms of the oral cavity, oropharynx or skull base (Cohort 1)
- Patients currently planned for treatment with radiotherapy and/or antiresorptive or antiangiogenic medication therapy (Cohort 1)
- Patients with a clinical diagnosis of osteoradionecrosis or medication-related osteonecrosis of the jaw following cancer treatment (Cohort 2)
- Patients previously planned for treatment with radiotherapy and/or antiresorptive or antiangiogenic medication therapy (Cohort 2)
You will not qualify if you...
- Patients unable to tolerate diffusion-weighted or dynamic contrast-enhanced MRI or with an estimated glomerular filtration rate less than 30 ml/min/1.73m2
- Patients with contraindications to MRI, such as non-MRI compatible metallic implants
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Stephen Y. Lai
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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