Actively Recruiting
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
Led by Laval University · Updated on 2023-11-15
214
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
Sponsors
L
Laval University
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
CONDITIONS
Official Title
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years with a first episode of STEMI and documented coronary obstruction
- Left ventricular ejection fraction (LVEF) less than 50% with mitral tenting area of 4 cm2 or more, OR LVEF 40% or less with inferior/posterior wall motion anomaly, OR LVEF 30% or less with wall motion in any territory
You will not qualify if you...
- Unable to provide informed consent
- Hemodynamic instability, cardiogenic shock, or papillary muscle rupture
- Prior mitral valve surgery or procedures
- Permanent atrial fibrillation that limits imaging and MR quantification
- Primary mitral valve disease such as endocarditis, rheumatic, degenerative, or congenital
- More than mild valvular disease other than mitral valve at baseline
- Planned cardiac surgery like CABG or valve intervention within 3 months
- Contraindications for MRI
- Current treatment with selective serotonin reuptake inhibitors (SSRIs)
- Chronic use of sedative medications
- Ongoing or planned pregnancy
- Chronic kidney failure with eGFR below 30 mL/min
- Neurocognitive disorders
- History or symptoms of urinary obstruction or glaucoma (relative contraindications for cyproheptadine)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Canada, G1V 4G5
Actively Recruiting
Research Team
J
Jonathan Beaudoin, MD
CONTACT
O
Ons Marsit, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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