Actively Recruiting
Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG
Led by Kartal Kosuyolu High Speciality Training and Research Hospital · Updated on 2026-02-17
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pain after cardiac surgery is commonly moderate to severe due to sternotomy, thoracotomy, internal mammary artery harvesting, and chest tube placement, and may contribute to adverse systemic and pulmonary outcomes if inadequately managed. Enhanced Recovery After Surgery (ERAS) protocols emphasize opioid-sparing strategies to reduce opioid-related side effects and complications. Ultrasound-guided fascial plane blocks have increasingly been incorporated into perioperative analgesia protocols for cardiac surgery. The serratus posterior superior intercostal plane block (SPSIPB), a recently described technique, provides wide dermatomal sensory coverage and may offer effective analgesia in thoracic and cardiac surgical procedures. This prospective, randomized controlled study aims to evaluate the analgesic efficacy of SPSIPB in adult patients undergoing off-pump minimally invasive coronary artery bypass grafting (CABG). A total of 60 ASA III patients aged 18 years or older will be randomized into two groups: SPSIPB group and control group. The SPSIPB will be performed preoperatively under ultrasound guidance using 0.25% bupivacaine, while the control group will receive standard general anesthesia without any plane block. All patients will receive standardized general anesthesia and postoperative patient-controlled analgesia with tramadol. The primary outcome of the study is postoperative recovery quality assessed using the Quality of Recovery-15 (QoR-15) questionnaire. Secondary outcomes include intraoperative remifentanil consumption, postoperative opioid requirements, time to first rescue analgesia, numerical rating scale (NRS) pain scores at rest and during coughing, extubation time, intensive care unit and hospital length of stay, and postoperative complications such as nausea, vomiting, and atelectasis. This study aims to determine whether SPSIPB can improve postoperative recovery quality and reduce opioid consumption in patients undergoing off-pump minimally invasive CABG.
CONDITIONS
Official Title
Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 75 years
- ASA physical status II or III
- Scheduled for elective off-pump minimally invasive coronary artery bypass grafting surgery
- Able to understand and use the Numerical Rating Scale (NRS)
- Able to provide written informed consent
You will not qualify if you...
- Refusal to participate in the study
- Known allergy or contraindication to local anesthetics
- Coagulation disorders or incompatible anticoagulant therapy
- Infection at the block injection site
- Severe liver or kidney dysfunction
- Chronic opioid use or opioid dependence
- History of chronic pain syndromes
- Severe lung disease such as advanced COPD
- Neurological or psychiatric disorders affecting pain assessment
- Emergency surgery
- Conversion to on-pump CABG or sternotomy during surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kosuyolu High Specialization Training and Research Hospital
Istanbul, Turkey (Türkiye), 34870
Actively Recruiting
Research Team
M
Mustafa Burgaç, himself
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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