Monitoring Serum FSH Levels to Find the Best Range for Ovarian Stimulation in Women Aged 18 to 39

What this Trial Is About

Researchers are studying how monitoring serum Follicle Stimulating Hormone FSH levels during ovarian stimulation can help predict the number of eggs produced and progesterone levels. The study considers factors such as age, baseline FSH, Antral Mullerian Hormone AMH, antral follicle count, body weight, kidney function, and urinary FSH. The goal is to identify a minimum FSH level that ensures an optimal ovarian response and supports personalized FSH dosing for better results. Women undergoing ovarian stimulation will receive a fixed daily dose of 300 IU Gonal-F hormone starting on cycle day 2 or 3, injected at 8 pm. From day 5 of stimulation, they will also get daily Cetrotide injections at 8 am until the day of ovulation trigger. Blood and urine samples will be collected on several days during stimulation to assess hormone levels. Ovulation will be triggered with hormones based on follicle size and hormone levels, and egg retrieval will occur 36 hours after the trigger. Participants will be assessed through blood and urine tests, ultrasound monitoring, and measurements of hormone levels including serum FSH. Follicular fluid from the largest follicle will also be tested for FSH on egg retrieval day. Researchers will track serum FSH levels quantitatively over one year. The study aims to better understand hormone levels during ovarian stimulation to improve treatment personalization and outcomes.

Serum FSH Monitoring for Identification of an Optimal Range During Ovarian Stimulation