Actively Recruiting
Severe COVID-19 Infection in Children Presenting to EDs in Israel and England
Led by Hadassah Medical Organization · Updated on 2025-03-14
500
Participants Needed
6
Research Sites
100 weeks
Total Duration
On this page
Sponsors
H
Hadassah Medical Organization
Lead Sponsor
L
London North West Healthcare NHS Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Even though the COVID-19 pandemic is no longer at its peak, the threat still lingers. Engaging in prospective surveillance studies will enable us to monitor the disease and prepare for any potential resurgence. COVID-19 surveillance studies are essential tools for policymakers to make informed decisions, allocate resources, and develop strategies to control the spread of the virus and protect public health. The objective of this surveillance study is to prospectively assess in-hospital severe morbidity related to COVID-19 infection in children who present to the Pediatric Emergency Department (ED). A prospective multicenter study will be conducted across eight EDs in Israel and five EDs in the United Kingdom. The study population will include children aged 16 years or younger with a severe acute COVID-19 infection. Confirmation of acute COVID-19 infection will be based on polymerase chain reaction nasopharyngeal swab testing. The study will also include patients diagnosed with multisystem inflammatory syndrome in children (MIS-C), as defined by the CDC.
CONDITIONS
Official Title
Severe COVID-19 Infection in Children Presenting to EDs in Israel and England
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 16 years or younger with positive COVID-19 PCR nasopharyngeal swab or bronchoalveolar sample
- Patients meeting severe acute COVID-19 infection criteria requiring oxygen support, mechanical ventilation, ECMO, or ICU admission
- Patients aged 16 years or younger diagnosed with multisystem inflammatory syndrome in children (MIS-C)
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Haemek Medical Center
Afula, Israel
Actively Recruiting
2
Soroka Medical Center
Beersheba, Israel
Actively Recruiting
3
Hadassah Medical Center
Jerusalem, Israel
Actively Recruiting
4
Shaare Zedek Medical Center
Jerusalem, Israel
Actively Recruiting
5
Meir Medical Center
Kfar Saba, Israel
Actively Recruiting
6
Sheba Medical Center
Tel Litwinsky, Israel
Actively Recruiting
Research Team
I
Itai Shavit, MD
CONTACT
H
Hadas Lamberg, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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