Comparing Sevoflurane With or Without Intravenous Lidocaine and Propofol Anesthesia on Brain Pressure and Oxygen Levels During Laparoscopic Hysterectomy

What this Trial Is About

Researchers are studying the effects of different anesthesia methods on brain pressure and oxygen levels during laparoscopic hysterectomy. The study compares sevoflurane alone, sevoflurane combined with intravenous lidocaine, and propofol total intravenous anesthesia TIVA. Previous studies suggested propofol might better reduce brain pressure compared to inhaled anesthesia, but this study aims to evaluate these methods using non-invasive monitoring. Participants will be randomly assigned to one of three groups propofol infusion adjusted to maintain a specific brain activity level, sevoflurane with intravenous lidocaine given before and during surgery, or sevoflurane alone with similar brain activity monitoring. The lidocaine is given as a bolus dose before anesthesia and continued through surgery. All anesthesia is adjusted to keep brain activity within a target range. During and after surgery, researchers will monitor optic nerve sheath diameter to assess brain pressure, cerebral oxygenation, and cognitive function. These measures will be taken up to one hour after removing the breathing tube and cognitive tests four hours after surgery. The study will also track complications within 24 hours post-surgery. Participation involves monitoring and assessments before, during, and after surgery, lasting up to 24 hours after the procedure.

Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy