Actively Recruiting
Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy
Led by Tanta University · Updated on 2025-07-14
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of different anesthesia methods on brain pressure and oxygen levels during laparoscopic hysterectomy. The study compares sevoflurane alone, sevoflurane combined with intravenous lidocaine, and propofol total intravenous anesthesia (TIVA). Previous studies suggested propofol might better reduce brain pressure compared to inhaled anesthesia, but this study aims to evaluate these methods using non-invasive monitoring. Participants will be randomly assigned to one of three groups: propofol infusion adjusted to maintain a specific brain activity level, sevoflurane with intravenous lidocaine given before and during surgery, or sevoflurane alone with similar brain activity monitoring. The lidocaine is given as a bolus dose before anesthesia and continued through surgery. All anesthesia is adjusted to keep brain activity within a target range. During and after surgery, researchers will monitor optic nerve sheath diameter to assess brain pressure, cerebral oxygenation, and cognitive function. These measures will be taken up to one hour after removing the breathing tube and cognitive tests four hours after surgery. The study will also track complications within 24 hours post-surgery. Participation involves monitoring and assessments before, during, and after surgery, lasting up to 24 hours after the procedure.
CONDITIONS
Brief Title
Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 65 years.
- Female gender.
- American Society of Anesthesiologists (ASA) physical status I and II.
- Body mass index (BMI) 35 or less.
- Scheduled for laparoscopic hysterectomy.
You will not qualify if you...
- Refusal to participate in the study.
- Allergy or hypersensitivity to study drugs.
- Eye diseases or history of eye surgery affecting optic nerve assessment.
- Central nervous system or cardiovascular disease.
- Severe liver or kidney impairment.
- Inability to perform optic nerve sheath diameter measurement during surgery.
- Conversion to open surgery during the procedure.
- Peak inspiratory pressure exceeding 35 during surgery.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the laparoscopic hysterectomy surgery
Participants receive anesthesia with either propofol infusion, sevoflurane with intravenous lidocaine infusion, or sevoflurane alone during laparoscopic hysterectomy surgery.
1 surgical visit
Duration - Up to 24 hours postoperatively
Participants are monitored for cerebral oxygenation, cognitive function, and postoperative complications after surgery.
Approximately 3 visits within 24 hours post-surgery
Trial Site Locations
Total: 1 location
1
Tanta University
Tanta, El-Gharbia, Egypt, 31527
Actively Recruiting
Research Team
E
Eman A Elrefaey, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here