Actively Recruiting

Phase 2
Age: 21Years - 45Years
All Genders
NCT07225777

Sex Differences in Neurobehavioral Response to THC

Led by Medical University of South Carolina · Updated on 2026-05-06

40

Participants Needed

1

Research Sites

87 weeks

Total Duration

On this page

Sponsors

M

Medical University of South Carolina

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

CONDITIONS

Official Title

Sex Differences in Neurobehavioral Response to THC

Who Can Participate

Age: 21Years - 45Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 21 to 45 years
  • Meet DSM-5 criteria for cannabis use disorder
  • Use cannabis at least 4 days per week
  • Positive urine test for THC
  • Body mass index between 18 and 30
  • Regular menstrual cycle (females only)
  • Willing to use non-hormonal birth control (females only)
Not Eligible

You will not qualify if you...

  • History of lifetime psychotic or bipolar disorder
  • Recent use of drugs other than cannabis
  • Current use of psychotropic medications
  • Currently seeking treatment for substance use disorder
  • Current psychiatric disorders except mild alcohol, nicotine, or caffeine use disorder
  • Pregnant or breastfeeding
  • Contraindications for MRI scanning

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Medical University of South Carolina

Charleston, South Carolina, United States, 29403

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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