Actively Recruiting
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-04-06
30
Participants Needed
1
Research Sites
324 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
D
Doris Duke Charitable Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, skeletal muscle bioenergetics, cardiopulmonary exercise capacity, and patient-reported functional outcomes.
CONDITIONS
Official Title
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Type 2 Diabetes Mellitus
- Class II-III New York Heart Association (NYHA) heart failure with reduced ejection fraction (EF) less than 50%
- Age between 18 and 80 years
- Body Mass Index (BMI) between 23 and 38 kg/m2
- Glycated hemoglobin (HbA1c) between 5.5% and 10%
- Blood Pressure (BP) less than or equal to 145/85 mmHg
- Estimated glomerular filtration rate (eGFR) of at least 30 ml/min/1.73 m2
- Stable dose of guideline-directed medications for heart failure and diabetes
- Stable body weight within plus or minus 4 pounds over the last 3 months
- No severe claustrophobia
- No contraindications for MRI (no metal plates, screws, shrapnel, pins, or cardiac pacemaker)
You will not qualify if you...
- Current treatment with an SGLT2 inhibitor, glucagon-like peptide-1 receptor agonist (GLP-1 RA), or pioglitazone
- Pregnancy, lactation, or plans to become pregnant
- Allergy or sensitivity to study drugs or their ingredients
- Cancer
- Current drug or alcohol use or dependence
- Inability or unwillingness to provide written informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
C
Carolina Solis-Herrera, MD
CONTACT
F
Francisca M Acosta, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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