Actively Recruiting

Phase 3
Age: 20Years +
All Genders
NCT06142474

SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning

Led by National Taiwan University Hospital · Updated on 2023-11-21

450

Participants Needed

1

Research Sites

417 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from ventilators.

CONDITIONS

Official Title

SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning

Who Can Participate

Age: 20Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged �3E=�20 years
  • Hospitalized with acute heart failure with reduced ejection fraction (LVEF �3C=�40%)
  • Stabilized with systolic blood pressure �3E=�100 mm Hg and no hypotension symptoms in last 6 hours
  • No increase in intravenous diuretics in last 6 hours
  • No intravenous vasodilators or nitrates in last 6 hours
  • No intravenous inotropic drugs in last 24 hours
  • Elevated NT-proBNP or BNP levels based on presence or absence of atrial fibrillation
  • Intubated for at least 24 hours with ventilator settings allowing initiation of weaning (SpO2 �3E�90% or PaO2/FiO2 �3E=�150 mmHg with FiO2 �3C=�40% and PEEP �3C=�8 cmH2O)
Not Eligible

You will not qualify if you...

  • Decision made to withdraw life support
  • Cardiogenic shock
  • Heart failure hospitalization triggered by acute myocardial infarction or pulmonary embolism
  • Planned or recent (within 30 days) major heart surgery, intervention, or device implantation
  • Recent (within 90 days) acute coronary syndrome, myocardial infarction, stroke, or transient ischemic attack
  • Estimated glomerular filtration rate less than 30 ml/min/1.73 m2
  • Type 1 diabetes mellitus
  • Poorly controlled type 2 diabetes mellitus (glycated hemoglobin above 10.5%)
  • Uncontrolled urinary tract infection

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

National Taiwan University Hospital

Taipei, Taiwan, 100

Actively Recruiting

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Research Team

C

Chih Fan Yeh

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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