Actively Recruiting
SHengXIaN-QuYu DEcoction in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
Led by China-Japan Friendship Hospital · Updated on 2025-04-08
336
Participants Needed
26
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to conduct a multicenter, randomized clinical trial to evaluate the effect of "ShengXian-QuYu Decoction" on quality of life , symptoms, and biomarkers in heart failure patients with reduced and mildly reduced ejection fraction.
CONDITIONS
Official Title
SHengXIaN-QuYu DEcoction in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older at the time of consent
- Established documented diagnosis of symptomatic heart failure with reduced ejection fraction (NYHA class II-IV)
- Left ventricular ejection fraction less than 50%
- NT-proBNP greater than 600 pg/ml or BNP greater than 150 pg/ml, or lower thresholds if hospitalized for heart failure within the previous 12 months
- Signed informed consent provided before any study procedures
You will not qualify if you...
- Acute decompensated heart failure or hospitalization for heart failure, acute coronary syndrome, stroke, TIA, coronary or valvular surgery within 4 weeks before enrollment
- Uncontrolled severe arrhythmia
- Planned heart transplantation or device implantation
- Significant liver impairment with AST or ALT over 3 times the upper normal limit or total bilirubin over 2 times the upper normal limit
- Severe infection
- eGFR less than 30 mL/min/1.73 m²
- Active malignancy requiring current treatment
- Women of child-bearing potential not using reliable contraception, pregnant or breastfeeding
- Any condition with life expectancy under 1 year outside cardiovascular and renal diseases
- Blood pressure below 90 mmHg systolic or above 180 mmHg systolic or 110 mmHg diastolic on two measurements
- Heart failure caused by infiltrative cardiomyopathies, fulminant myocarditis, or constrictive pericarditis
- Participation in another clinical study
- Inability to understand or comply with study procedures or medications as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 26 locations
1
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
2
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
3
Beijing Fengtai Hospital of Integrated Traditional Chinese and Western Medicine
Beijing, Beijing Municipality, China, 100072
Actively Recruiting
4
Dongcheng District First People's Hospital
Beijing, Beijing Municipality, China, 100077
Actively Recruiting
5
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Beijing, Beijing Municipality, China, 100078
Actively Recruiting
6
Huairou District Traditional Chinese Medicine Hospital of Beijing
Beijing, Beijing Municipality, China, 101400
Actively Recruiting
7
Beijing Changping Nankou Hospital
Beijing, Beijing Municipality, China, 102202
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8
Changping District Traditional Chinese Medicine Hospital
Beijing, Beijing Municipality, China, 102208
Actively Recruiting
9
Tang County Hospital of Traditional Chinese Medicine
Baoding, Hebei, China, 072350
Actively Recruiting
10
Funing Hospital of Traditional Chinese Medicine
Qinhuangdao, Hebei, China, 066399
Actively Recruiting
11
Gongyi City Public Hospital of TCM
Gongyi, Henan, China, 451200
Actively Recruiting
12
Yangzhou Hospital of Traditional Chinese Medicine
Yangzhou, Jiangsu, China, 225127
Actively Recruiting
13
Jining Hospital of Traditional Chinese Medicine
Jining, Shandong, China, 272004
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14
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China, 266071
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15
The Affiliated Hospital of Changzhi Institute of Traditional Chinese Medicine
Changzhi, Shanxi, China, 046000
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16
Changzhi Medical College Affiliated Heji Hospital
Changzhi, Shanxi, China, 046011
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17
Changzhi Hospital of Traditional Chinese Medicine
Changzhi, Shanxi, China, 046099
Actively Recruiting
18
Chengdu Integrated TCM and Western Medicine Hospital
Chengdu, Sichuan, China, 610095
Actively Recruiting
19
Jixian Chinese Traditional Hospital
Tianjin, Tianjin Municipality, China, 301900
Actively Recruiting
20
Urumqi Hospital of Traditional Chinese Medicine
Ürümqi, Xinjiang, China, 830000
Actively Recruiting
21
Korla Hospital of Traditional Chinese Medicine
Bayan Gol Autonomous Prefecture, Xinjiang Uygur Autonomous Region, China, 841009
Actively Recruiting
22
Changji Hospital of Traditional Chinese Medicine
Changji Hui Autonomous Prefecture, Xinjiang Uygur Autonomous Region, China, 831199
Actively Recruiting
23
Gulja Hospital of Traditional Chinese Medicine
Ili Kazakh Autonomous Prefecture, Xinjiang Uygur Autonomous Region, China, 835199
Actively Recruiting
24
Zhaosu Hospital of Traditional Chinese Medicine
Ili Kazakh Autonomous Prefecture, Xinjiang Uygur Autonomous Region, China, 835699
Actively Recruiting
25
Xinyuan Traditional Chinese Medicine Hospital
Ili Kazakh Autonomous Prefecture, Xinjiang Uygur Autonomous Region, China, 835899
Actively Recruiting
26
Linhai Hospital of Traditional Chinese Medicine
Linhai, Zhejiang, China, 317000
Actively Recruiting
Research Team
M
Mengxi Yang, Dr.
CONTACT
J
Jiang Liu, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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