Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05903170

Shock Energy for Electrical Cardioversion of Persistent Atrial Fibrillation

Led by Wellington Hospital · Updated on 2025-04-01

100

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to compare the efficacy of a maximum output shock for cardioverting atrial fibrillation between two commonly used defibrillators in New Zealand . These machines have different maximum energy outputs, and to date no head-to-head comparison cardioverting atrial fibrillation between the two has been undertaken. The main question it aims to answer is whether either device is more likely to cardiovert patients referred for atrial fibrillation. Participants will be randomized to undergo cardioversion with one of two defibrillators at either 200J or 360J. Participants in each arm will undergo up to three shocks at the energy-level to which they have been randomized, using a standardized procedure. For participants randomized to the lower energy level who fail to return to normal rhythm after three shocks, they will be given a fourth shock at the higher energy level. All participants will then be asked to undertake a blood test the day following the cardioversion, and receive a follow up phone call. These are to ensure there is no difference in the safety of the procedure between the two energy levels. It is worth noting that these two components of the study (the blood test and phone call) are the only additional time commitment that is expected to be involved if you choose to participate in the study.

CONDITIONS

Official Title

Shock Energy for Electrical Cardioversion of Persistent Atrial Fibrillation

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age over 18
  • Patients undergoing elective outpatient or non-emergent inpatient cardioversion for atrial fibrillation
  • Eligible for anticoagulation
  • Reliably anticoagulated for at least three weeks prior to cardioversion, or atrial fibrillation onset within 48 hours of cardioversion, or left atrial thrombus excluded on transoesophageal echocardiogram
  • Able to provide consent for cardioversion and study participation
Not Eligible

You will not qualify if you...

  • Contraindication to anticoagulation
  • Diagnosis of atrial flutter
  • Need for emergent cardioversion
  • Presence of implantable cardiac device such as pacemaker or implantable cardioverter defibrillator
  • Unable to consent to cardioversion and/or study participation
  • Pregnancy

AI-Screening

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Trial Site Locations

Total: 1 location

1

Wellington Regional Hospital

Wellington, Wellington Region, New Zealand, 6012

Actively Recruiting

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Research Team

A

Allan M Plant, FRACP

CONTACT

D

Darren Hooks, FRACP

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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