Actively Recruiting
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
Led by Jonsson Comprehensive Cancer Center · Updated on 2026-03-30
25
Participants Needed
1
Research Sites
348 weeks
Total Duration
On this page
Sponsors
J
Jonsson Comprehensive Cancer Center
Lead Sponsor
T
The Joseph Drown Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase I trial investigates how well short-course radiation therapy followed by combination chemotherapy works in treating patients with stage II-III rectal cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as leucovorin, fluorouracil, oxaliplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving short-course radiation therapy and combination chemotherapy may reduce the need for surgery and therefore improve quality of life.
CONDITIONS
Official Title
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed rectal adenocarcinoma
- Stage II (cT3, cN0) or stage III (cT1-3, cN1-3) tumor confirmed by MRI
- No evidence of metastatic disease
- Resectable primary tumor
- Karnofsky performance status (KPS) of 70 or higher or ECOG score 0-2
- Absolute neutrophil count greater than 1.5 cell/mm^3
- Hemoglobin level greater than 8.0 gm/dL
- Platelet count greater than 150,000/mm^3
- Total bilirubin at or below 1.5 times the upper limit of normal
- AST and ALT enzymes at or below three times the upper limit of normal
- Negative pregnancy test for women of childbearing potential before starting radiation therapy
You will not qualify if you...
- Active treatment for a separate cancer
- Distant metastatic disease shown by PET/CT or chest and abdomen CT within 6 weeks before radiation therapy
- Previous radiation therapy to the pelvic area overlapping the study treatment fields
- Pregnant or breastfeeding
- Medical or psychological conditions preventing MRI examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
V
Vincent Basehart
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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