Actively Recruiting
Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
Led by University of Utah · Updated on 2025-12-12
188
Participants Needed
5
Research Sites
612 weeks
Total Duration
On this page
Sponsors
U
University of Utah
Lead Sponsor
H
Huntsman Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.
CONDITIONS
Official Title
Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed endometrial carcinoma including endometrioid, serous, clear cell types, carcinosarcoma, or other sarcomas
- Cancer stage I or II (including stage IIIA without external beam radiotherapy), with specified combinations of stage and grade
- Completed hysterectomy and free from residual disease
- Performance status of 0 to 2 according to WHO/ECOG criteria
- Able to provide informed consent
- Life expectancy greater than 2 years
You will not qualify if you...
- Endometrial carcinoma stages other than those specified in the inclusion criteria
- Previous pelvic radiotherapy
- Concurrent cancer requiring anti-cancer treatment other than surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Stanford Cancer Center
Palo Alto, California, United States, 94304
Completed
2
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
3
MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
4
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
5
Intermountain Medical Center / LDS Hospital
Salt Lake City, Utah, United States, 84143
Completed
Research Team
R
Rachel Kingsford
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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