Actively Recruiting
Short Infusion Versus Prolonged Infusion of Ceftolozane-tazobactam Among Patients with Ventilator Associated-pneumonia
Led by University Hospital, Toulouse · Updated on 2024-09-25
80
Participants Needed
1
Research Sites
332 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective of this study is to compare the median exposures at pharmacokinetic equilibrium of the two modalities of administration: 4-hours infusion of ceftolozane-tazobactam at a dosage of 2 gram three times a day vs 1-hour infusion of 2 gram three times a day.
CONDITIONS
Official Title
Short Infusion Versus Prolonged Infusion of Ceftolozane-tazobactam Among Patients with Ventilator Associated-pneumonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
- Hospitalized in intensive care units
- Pseudomonas aeruginosa susceptible to ceftolozane-tazobactam
- Simplified Acute Physiological Score II (SAPS II) greater than 20
- Expected survival longer than 7 days
- Informed consent obtained from patient or authorized representative
- Affiliated to a social security scheme or equivalent
You will not qualify if you...
- History of allergy to ceftolozane-tazobactam or beta-lactam antibiotics
- Infection caused by strains resistant to ceftolozane-tazobactam
- Renal insufficiency with glomerular filtration rate less than 50 ml/min
- On dialysis or receiving continuous hemodiafiltration
- Pregnant or breastfeeding women
- Under legal protection for adults
- Active immunodepression
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Service Réanimation Polyvalente - CHU Rangueil
Toulouse, France, 31059
Actively Recruiting
Research Team
S
Stéphanie RUIZ, MD
CONTACT
N
Nathalie ROQUES
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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