Actively Recruiting

Age: 20Years - 50Years
All Genders
NCT07567560

The Short Sleep Study

Led by Danisco · Updated on 2026-05-05

34

Participants Needed

4

Research Sites

53 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Natural Short Sleepers are defined as individuals who sleep fewer than 6 hours per night without any impact on health or daytime mental fatigue levels. Emerging evidence suggests that, in the general population, the gut microbiota would be negatively influenced by this sleep duration. It is possible that Natural Short Sleepers have a distinct gut microbiome. Identifying differences in microbiota composition may lead to an opportunity to improve health outcomes in those with inadequate or poor sleep.

CONDITIONS

Official Title

The Short Sleep Study

Who Can Participate

Age: 20Years - 50Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Men between 20 and 50 years of age and pre-menopausal women between 20 and 45 years of age
  • Consistent daytime schedule
  • Body Mass Index (BMI) between 18.5 and 35 kg/m2
  • Good physical and mental health based on self-report and investigator evaluation
  • Willingness to maintain and record usual habits, diet, and daily activity/exercise during the study
  • Willingness to maintain typical sleep hygiene (sleep location, temperature, environment)
  • Willingness to keep current alcohol consumption pattern during the study
  • Willing and able to participate fully and provide signed informed consent
  • Willing and able to attend two in-person visits at the study site
  • Completion of all required screening procedures and questionnaires during a 14-day screening period
  • Regular bowel habits at least 5 days per week
  • Pittsburgh Sleep Quality Index (PSQI) score of 5 or less during screening
  • Sleep on average 4 to 5.5 hours per night verified by self-report during screening
  • Feeling refreshed with no desire to nap during the day, with an Epworth Sleepiness Scale (ESS) score of 4 or less during screening
  • Average Karolinska Sleepiness Scale (KSS) score between 1 and 3 during screening
Not Eligible

You will not qualify if you...

  • Diagnosed or self-reported sleep disorders including sleep apnea, habitual snoring, insomnia, narcolepsy, or parasomnias
  • Extreme chronotypes sleeping regularly before 8:00pm
  • Diagnosed or self-reported gastrointestinal disorders such as Crohn's disease, ulcerative colitis, celiac disease, irritable bowel syndrome, or chronic heartburn
  • Waking up 5 or more times per night totaling 30 minutes or more
  • Use of medications or supplements affecting microbiome or sleep currently or in the past 3 months
  • Neurodegenerative diseases like multiple sclerosis, Parkinson's, Alzheimer's, or dementia
  • Recent history of alcohol abuse or dependence
  • Drug abuse or recreational substance use including marijuana
  • Recent binge drinking behavior
  • Recent smoking, vaping, or nicotine product use
  • Diagnosed neuropsychiatric disorders affecting sleep such as anxiety, depression, bipolar disorder, or schizophrenia
  • Use of systemic antibiotics in past 3 months
  • Use of probiotics in past 2 weeks
  • Use of proton pump inhibitors in past 2 weeks
  • Use of laxatives or antidiarrheals in past 4 weeks
  • Use of NSAIDs for 5 or more consecutive days in past 4 weeks
  • Pregnancy, breastfeeding, or planning pregnancy
  • Personal circumstances causing stress or sleep challenges
  • Planned overnight travel during the study
  • Perimenopausal or menopausal females
  • Diagnosed or undiagnosed conditions disrupting sleep
  • Varying work schedules or overnight shift work
  • Any other condition that may bias or confound study results

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 4 locations

1

Global Life Research Network

Miami, Florida, United States, 33155

Actively Recruiting

2

Lindus Health

Boston, Massachusetts, United States, 02111

Actively Recruiting

3

AccuMed

Garden City, New York, United States, 11530

Actively Recruiting

4

New Dawn Wellness and Medical Research Center

Houston, Texas, United States, 77082

Actively Recruiting

Loading map...

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here