Actively Recruiting
Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial
Led by Population Health Research Institute · Updated on 2025-08-12
400
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The START-POAF pilot study is a prospective, open-label two-arm, randomized controlled trial with blinded assessment of outcomes (PROBE). This pilot study will assess Atrial Fibrillation (AF) recurrence and burden in patients with new-onset AF following cardiac surgery.
CONDITIONS
Official Title
Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Underwent cardiac surgery including CABG, valve surgery, ascending aorta replacement, or combinations within 14 days of randomization
- New-onset postoperative atrial fibrillation (or flutter), documented by 12-lead ECG or lasting at least 1 hour on telemetry
- Expected to receive 3 g to 5 g of amiodarone loading dose after surgery
- Expected to be ready for hospital discharge within 48 hours of randomization
You will not qualify if you...
- History of paroxysmal, persistent, or permanent atrial fibrillation before surgery
- Planned use of class I or III anti-arrhythmic drugs other than the study drug
- Underwent heart transplant, complex congenital heart surgery, ventricular assist device insertion, or AF ablation
- Known allergy to ECG adhesives
- Contraindications to amiodarone including hyperthyroidism, severe lung disease, Long QT syndrome, PR interval over 240 ms, or high-grade AV block
- Pregnant, breastfeeding, or females of childbearing potential not using effective birth control
- Positive pregnancy test at screening
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
Research Team
I
Ingrid Copland
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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