The Effect of Short-term Overconsumption of Specific Dietary Nutrients on Liver and Adipose Tissue Metabolism

What this Trial Is About

Researchers are investigating how the type and amount of dietary fat affect liver fat content, cardiac function, and metabolism after eating. The study compares two high-fat diets in healthy adults without medical conditions or drugs affecting fat, glucose, or liver metabolism. It aims to clarify the effects of saturated versus unsaturated fatty acids on these health factors without changes in body weight. Participants will be randomly assigned to one of two diets for about 28 days: one diet high in saturated fatty acids and the other high in unsaturated fatty acids. Both diets provide about 60% of total energy from fat but differ in fat type proportions. Before and after the diet period, participants will undergo MRI scans to measure liver fat, cardiac fat, and heart function, along with a metabolic test day to assess their body's response to a test meal. During the study, participants will have detailed assessments including MRI scans and blood tests to measure liver fat and post-meal metabolism before and after the diet intervention. Researchers will monitor changes in liver fat and postprandial plasma biochemistry to understand metabolic effects. The study duration for each participant includes the baseline assessments, a 28-day diet period, and follow-up evaluations to measure the impact of the fat composition on metabolism and heart health.

Short-term Fat Overfeeding on the Effects of Liver Metabolism