Actively Recruiting
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Led by University of Oxford · Updated on 2023-07-27
26
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.
CONDITIONS
Official Title
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent
- Male or female aged 18 to 65 years
- Body Mass Index between 19 and 35 kg/m2
- No medical condition or medication that affects liver or fat metabolism
- Weight stable for the past 3 months
You will not qualify if you...
- Unwilling or unable to give informed consent
- Aged under 18 or over 65 years
- Body Mass Index under 19 or over 35 kg/m2
- Blood hemoglobin below 135 mg/dL for men or 120 mg/dL for women
- Donated or lost 250 ml or more of blood in the last 2 months
- Currently on a weight loss diet or lost more than 5% body weight in past 3 months
- Gained more than 5% body weight in past 3 months
- Any metabolic condition or relevant drug therapy
- Current smoker
- History of alcoholism or alcohol intake above recommended levels
- Hemorrhagic disorders
- Taking anticoagulant treatment
- History of albumin allergy
- Pregnant or nursing
- Using contraceptive agents or hormone therapies in last 12 months
- Severe claustrophobia
- Presence of metallic implants or pacemakers
- History of eating disorder or psychological condition affecting study adherence
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
Research Team
L
Leanne Hodson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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