Actively Recruiting
Short-term And Longer-term Cognitive Impact Of Neurochecks
Led by University of California, San Diego · Updated on 2025-09-10
120
Participants Needed
1
Research Sites
277 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent serial neurological examinations ("neurochecks") in an effort to monitor patients for neurological deterioration following brain injury. Many neurocritical patients are older and/or cognitively fragile, and delirium is common. Although ICU delirium is multifaceted, frequent neurochecks may represent a modifiable risk factor if the investigators can better understand the risks and benefits of various neurocheck frequencies. This project will randomize patients with acute spontaneous intracerebral hemorrhage (ICH) to either hourly (Q1) or every-other-hour (Q2) neurochecks and evaluate the impact of neurocheck frequency on delirium. Second, longer-term cognitive outcomes will be investigated in patients with ICH randomized to Q1 versus Q2 neurochecks with the goal of identifying whether hourly neurochecks increase the risk for dementia.
CONDITIONS
Official Title
Short-term And Longer-term Cognitive Impact Of Neurochecks
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients over 18 years old with spontaneous acute intracerebral hemorrhage less than 45cc in volume
- Radiographic and clinical stability for at least 6 hours after ICU admission
- Additional intraventricular hemorrhage with or without external ventricular drain allowed
- Only first NeuroICU admission during the hospital stay
- Patients alive at 6 months post-discharge
You will not qualify if you...
- Unstable intracranial bleeding
- Known history of intracranial neurological injury
- Pre-existing cognitive impairment based on history or family report
- Pre-existing diagnosed sleep disorder
- Comatose or heavily sedated patients
- Death expected within 30 days or terminal illness
- ICH score greater than 4 (high mortality risk)
- Pregnancy
- Incarcerated individuals
- Non-English or non-Spanish speaking patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UC San Diego Health
San Diego, California, United States, 92103
Actively Recruiting
Research Team
J
Jamie N LaBuzetta
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
2
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