Short-Term Nutritional Support Combined With Health Education to Improve Outcomes After Colorectal Cancer Surgery A Multicenter Randomized Trial

What this Trial Is About

Researchers are evaluating whether short-term personalized nutritional support combined with structured health education can improve nutritional status, quality of life, and clinical outcomes in patients who have undergone surgery for colorectal cancer. This trial focuses on patients with non-metastatic colorectal cancer stages IIa, IIb, and IIIa, addressing the common problem of malnutrition and poor physical condition during treatment that may affect recovery and survival. Participants are randomly assigned to one of four groups nutritional enhancement plus health education, health education alone, nutritional enhancement alone, or standard care without these interventions. Nutritional support includes personalized dietary counseling and oral or parenteral nutritional supplements tailored to individual energy and protein needs. Health education is delivered digitally via an Internet Plus platform with weekly videos and expert guidance, focusing on nutrition, exercise, and psychological well-being. The intervention phase lasts 14 days, followed by a 12-month follow-up and annual assessments up to 5 years. During the study, participants undergo assessments of nutritional status, quality of life, symptom scores, and survival at multiple time points including baseline, post-intervention, and several months afterward. Biological samples such as blood, stool, and tumor tissue are collected for analysis of metabolic, immune, and microbiome changes. Researchers also monitor treatment side effects, patient adherence, psychological health, and healthcare utilization. This comprehensive follow-up up to 5 years aims to provide evidence for integrating nutrition and health education into colorectal cancer care and to uncover biological mechanisms behind treatment effects.

Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial