Actively Recruiting
Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas
Led by Erasmus Medical Center · Updated on 2024-10-15
320
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
Sponsors
E
Erasmus Medical Center
Lead Sponsor
M
Medical Center Haaglanden
Collaborating Sponsor
AI-Summary
What this Trial Is About
Rationale: Proton beam therapy has recently become available for the treatment of patients with WHO grade 2 and 3 IDH mutated (IDHmt) glioma in the Netherlands. The dose distributions associated with proton therapy have substantially reduced the volume of the normal brain irradiated with low and intermediate radiotherapy doses. Whether this impacts rates of progressive disease or safety issues and how this compares with a similar population treated with photon therapy is currently unknown. Objective: To investigate short term outcomes after proton and photon radiotherapy for grade 2 and 3 IDHmt glioma.
CONDITIONS
Official Title
Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathologically confirmed WHO grade 2 or grade 3 IDH mutated glioma
- Radiotherapy treatment delivered between January 1, 2018, and completed on or before June 30, 2022
- Chemotherapy given after radiotherapy with PCV or Temozolomide
- Age 18 years or older
You will not qualify if you...
- Prior cranial radiotherapy
- Contraindication for MRI imaging
- Chemotherapy given before radiotherapy
- Radiotherapy dose and fractionation different from standard (50.4 Gy in 28 fractions for grade 2; 59.5 Gy in 33 fractions for grade 3)
- Combination of photon and proton therapy
- Patient previously opted out of use of their data for research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Erasmus MC
Rotterdam, Netherlands
Actively Recruiting
Research Team
S
Steven HJ Nagtegaal, MD PhD
CONTACT
A
Alejandra Mendez Romero, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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