Actively Recruiting
Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP
Led by Medical College of Wisconsin · Updated on 2026-03-02
236
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this open label, randomized, non-inferiority clinical trial is to compare the treatment success of a 5 day antibiotic course versus a standard antibiotic course (usually 7-14 days of antibiotics) in hospitalized children aged 3 months to 18 years, with uncomplicated community acquired pneumonia. The main questions it aims to answer are: * Does a 5 day course work as well as standard (longer) courses of antibiotics for treating community acquired pneumonia in children? * Does a 5 day course cause less antibiotic side effects compared to a standard (longer) course of antibiotics in children with community acquired pneumonia? Participants will * be randomly assigned to either receive 5 total days or a total duration decided by the treating physician * receive a brief follow up questionnaire regarding clinical symptoms, follow up care/antibiotics, and side effects via phone or email at days 5 and 14 from the start of antibiotics Researchers will compare the experimental group (receiving 5 days duration) with the control group (standard duration) to see if 5 days is as successful as a standard duration.
CONDITIONS
Official Title
Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 3 months to less than 18 years old
- Hospitalized in acute care or pediatric intensive care units
- Clinically diagnosed with uncomplicated bacterial community acquired pneumonia
- Radiological signs of pneumonia such as consolidation or infiltrates
- Achieved clinical stability within 72 hours of first antibiotic dose (off oxygen/ventilatory support, temperature less than 38 Celsius)
You will not qualify if you...
- Hemodynamic instability requiring inotropic support during hospitalization
- Need for respiratory support longer than 72 hours
- Parapneumonic effusion larger than 10 mm on x-ray or more than one quarter of hemithorax opacified
- Need for chest tube placement
- Infection outside the lungs except otitis media if treatment is 5 days or less
- Pneumonia caused by known staphylococcus aureus from cultures
- Antibiotic treatment started more than 72 hours after admission
- Antibiotics used for more than 24 hours within 2 weeks before admission
- Chronic respiratory illness other than asthma or reactive airway disease
- Immunocompromised status
- Refusal by primary physician or parent
- Non-English speaking
- Pregnant or lactating female
- Participant turning 18 years or older by day 14 follow-up
- Inability to adhere to follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Childrens Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
M
Michelle Mitchell, MD
CONTACT
K
Khaled AL zubaidi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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