Actively Recruiting
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)
Led by University Hospitals Cleveland Medical Center · Updated on 2025-08-21
100
Participants Needed
1
Research Sites
713 weeks
Total Duration
On this page
Sponsors
U
University Hospitals Cleveland Medical Center
Lead Sponsor
C
Case Western Reserve University
Collaborating Sponsor
AI-Summary
What this Trial Is About
'Sickle-shaped' anemia was first clinically described in the US in 1910, and the mutated heritable sickle hemoglobin molecule was identified in 1949. The pathophysiology of SCD is a consequence of abnormal polymerization of sickle hemoglobin (HbS) and its effects on red cell membrane properties, shape, and density, and subsequent critical changes in inflammatory cell and endothelial cell function. Our goal is to understand the impact of CMA abnormalities in SCD, by interrogating a number of recognized interactions in a range of clinical phenotypes. To date, correlative studies in SCD, by us and others, have range between clinical reports, based on tests, interventions, and chart review of individuals or groups of individuals and, at the other extreme, identification of functional gene polymorphisms based on population studies. The investigators wish to augment these studies through a systematic examination of cellular membrane properties and activation status. Of hematologic disorders, SCD may be unusually susceptible to such an examination.
CONDITIONS
Official Title
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 12 years of age or older at the time of consent
- Documented diagnosis of Sickle Cell Disease, including HbSS or compound heterozygous HbSC- or HbSβ-thalassemia
- Able to provide written informed consent or assent and comply with study requirements
You will not qualify if you...
- Any condition or abnormality that the Investigator believes would compromise patient safety or data quality
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Case Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
U
Umut Gurkan, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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