Actively Recruiting
Sigh Ventilation in Cardiac Surgery
Led by Zhongda Hospital · Updated on 2025-11-18
686
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.
CONDITIONS
Official Title
Sigh Ventilation in Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia
- Written informed consent obtained from patients and/or their legal representatives
You will not qualify if you...
- Emergency surgery
- Left ventricular assist device implantation
- Planned thoracotomy with one lung ventilation
- Concurrent surgical procedures outside cardiology
- Neuromuscular illness
- Mechanical ventilation within the last 2 weeks before surgery, including CPAP and NIV
- Preoperative shock
- Preoperative hypoxemia (PaO2 <60mmHg OR SpO2 <90% on ambient air)
- Preoperative left ventricular ejection fraction <40%
- Systolic pulmonary artery pressure >50 mmHg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
Research Team
Z
Zhichang Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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