Actively Recruiting
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries
Led by The University of Texas Medical Branch, Galveston · Updated on 2025-12-16
24
Participants Needed
2
Research Sites
281 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries.
CONDITIONS
Official Title
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with spinal cord injury aged 18 to 75 years at the time of consent
- Experience urinary incontinence with at least 3 leakage episodes per week
- Have urodynamics assessment on file from the past 3 years or complete one before study visit 1
- Willing and able to comply with all study procedures
- Willing and able to provide written informed consent
You will not qualify if you...
- Pleased with current urinary symptoms quality of life during phone prescreen
- Use of an indwelling catheter
- History of more than 4 urinary tract infections per year
- Diagnosis of multiple sclerosis
- Significant heart, liver, kidney, lung, blood, autoimmune, or peripheral vascular disease
- Blood pressure outside 90/50 to 170/110 mmHg range after repeated measurements
- Active cancer
- Infection with HIV, Hepatitis B, or Hepatitis C
- Use of systemic nitrates, anabolic steroids, corticosteroids, or long-acting PDE5 inhibitors in the past month
- Use of short-acting PDE5 inhibitors in the past week
- Use of alpha blockers, anticholinergic agents, bethanechol, or other urinary incontinence treatments within the past two weeks (three weeks for long-acting muscarinic receptor antagonists)
- Known allergy to study medications or required agents
- Females who are pregnant or breastfeeding
- Atonic bladder or high detrusor and pelvic floor muscle pressure placing risk for kidney injury
- Any medical condition that increases risk for participation as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Texas A&M University
College Station, Texas, United States, 77843
Active, Not Recruiting
2
University of Texas Medical Branch
Galveston, Texas, United States, 77555
Actively Recruiting
Research Team
K
Kate M Randolph, BS
CONTACT
K
Kathy Vincent, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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