Simplifying the Oral Sodium Loading Test for Diagnosing Primary Aldosteronism by Comparing 2-Day and 3-Day Urinary Aldosterone Measurements A Prospective Study Using Liquid Chromatography-tandem Mass Spectrometry

What this Trial Is About

Researchers are evaluating the consistency of 24-hour urinary aldosterone levels measured on the second and third days of an oral sodium loading test to diagnose primary aldosteronism. This exploratory, prospective study includes 17 healthy controls and 15 patients with primary aldosteronism. The goal is to determine if the aldosterone level on the second day can reliably replace the third day measurement for diagnosis, potentially simplifying the testing process. Participants follow a high-sodium diet for three consecutive days, with an additional 10 grams of salt per day. During this period, 24-hour urine samples are collected on both the second and third days to measure aldosterone, sodium, potassium, and creatinine levels. The study compares these measurements to assess the consistency between the two testing days. Throughout the study, participants undergo urine collections for laboratory analysis to monitor aldosterone and electrolyte levels. Researchers evaluate the primary outcome by measuring the consistency of 24-hour urinary aldosterone between the second and third days of the oral sodium load test. The total participation period involves the three-day dietary and urine collection phase, with close monitoring to ensure accurate data collection and safety.

Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method