Actively Recruiting
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Led by Cedars-Sinai Medical Center · Updated on 2026-02-27
90
Participants Needed
5
Research Sites
135 weeks
Total Duration
On this page
Sponsors
C
Cedars-Sinai Medical Center
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this pilot study to examine the feasibility and acceptability of simvastatin in adults with Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP).
CONDITIONS
Official Title
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and be available for the study duration
- Male or female, aged 18 to 75 years at enrollment
- Diagnosis of Recurrent Acute or Chronic Pancreatitis not due to gallstones, medications, trauma, or autoimmune pancreatitis
- Ability to take oral medication and willingness to follow dosing schedule
- For females of childbearing potential: use of highly effective contraception for at least 1 month before and during the study, and for 1 month after study medication
- For males of reproductive potential: use of condoms or effective contraception for at least 1 month before and during the study, and for 1 month after study medication
- No prior pancreatic surgery
- No use of statin medications in the past 6 months
You will not qualify if you...
- Pregnancy or breastfeeding
- History of autoimmune, medication-induced, or traumatic pancreatitis
- Presence of primary pancreatic tumors such as pancreatic ductal adenocarcinoma or neuroendocrine tumors
- Pancreatic metastasis from other cancers
- History of solid organ transplant or HIV/AIDS
- Known isolated pancreatic exocrine insufficiency without other eligible conditions
- Use of specific interacting medications like itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone, gemfibrozil, cyclosporine, danazol, amiodarone, or verapamil
- Current use of simvastatin within the past 6 months
- Medical or psychiatric conditions or substance abuse that would interfere with study participation
- Active liver disease
- Known pregnancy or positive pregnancy test within 2 days prior to research procedures
- Currently incarcerated
- Inability to comply with study activities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
University of Southern California
Los Angeles, California, United States, 90033
Actively Recruiting
2
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
3
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
4
Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
5
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Arax Shanlian
CONTACT
A
Arax Shanlian
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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