Actively Recruiting
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
Led by National Cancer Centre, Singapore · Updated on 2025-01-08
1000
Participants Needed
3
Research Sites
388 weeks
Total Duration
On this page
Sponsors
N
National Cancer Centre, Singapore
Lead Sponsor
S
Singapore General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing. The primary aim of the study is to determine the feasibility of conducting LDCT screening in at-risk populations for lung cancer in Singapore: * For the smoker population, LDCT screening for lung cancer will be implemented in accordance to Academy of Medicine, Singapore screening test guidelines with the aim of investigating the feasibility of instituting lung cancer screening clinical service in Singapore. * For the non-smoker population, LDCT screening for lung cancer will be introduced to systematically collect baseline data to better understand and provide evidence for lung adenocarcinoma in never-smoker phenotype that is unique to East Asia/Singapore. This will help address unmet needs in local population research as reported by Academy of Medicine, Singapore, to validate risk factors and inform future screening guidelines for the at-risk population. Screening results will be reported based on Lung CT Screening Reporting \& Data System (Lung-RADS).
CONDITIONS
Official Title
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is willing and able to give informed consent for participation in the study
- Male or female, aged 50-80 years
- No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment
- ECOG performance status 0 or 1
- Willing to comply with study follow-up schedule and tests
- Willing to cover costs of standard care management including doctor's fees, CT scans, and biopsies
- A Singapore citizen or Permanent Resident of Singapore
- Current or former smokers with at least 30 pack years of smoking history (for smoker group)
- Never smokers or those who smoked less than 10 pack-years and quit smoking for at least 15 years with family history of lung cancer up to 2nd degree relatives (for non-smoker group)
You will not qualify if you...
- Uncontrolled medical comorbidities at enrollment
- Previous diagnosis of cancer
- Bleeding disorders that prevent blood sampling
- Fear of blood draws or needles
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 3 locations
1
National Cancer Centre, Singapore
Singapore, Singapore, 168583
Actively Recruiting
2
Singapore General Hospital
Singapore, Singapore, 169608
Actively Recruiting
3
National Heart Centre Singapore
Singapore, Singapore, 169609
Actively Recruiting
Research Team
D
Darren Wan-Teck Lim, MD
CONTACT
G
Gillianne Geet-Yi Lai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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