Study of Lacrifill for Treating Dry Eye in Contact Lens Wearers Improving Comfort and Wear Time Over 2-3 Months

What this Trial Is About

This research study focuses on people who wear contact lenses but find it uncomfortable to wear them for long periods due to dry eye symptoms. The study aims to evaluate whether using Lacrifill regularly over a 2 to 3 month period can help people wear their contact lenses longer without discomfort and reduce signs and symptoms of dry eye. Lacrifill is a drug being studied for its potential to improve comfort for contact lens users with dry eye. Participants in this trial will use Lacrifill, a cross-linked hyaluronic acid derivative that temporarily blocks tear drainage to keep the eyes bathed in natural tears. This is a single-arm study without a comparison group, and the treatment will be used over 2 to 3 months. The study will monitor the effects of Lacrifill on dry eye symptoms and contact lens tolerability during this period. During the study, participants will be assessed through various questionnaires and clinical tests to measure dry eye signs, symptoms, and contact lens wear time. These include the CLDEQ-8 and OSDI questionnaires, tear break-up time, corneal staining, and Schirmers tear test. Safety and tolerability will be closely monitored throughout the study. The total participation time is about 2 to 3 months, with results focusing on changes in dry eye and contact lens comfort.

Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses