Study Using Single-cell and Spatial Omics to Understand Liver Diseases Including Fatty Liver, HBV Infection, Fibrosis, and Cirrhosis

What This Trial Is About

This observational study aims to use advanced single-cell multi-omics and spatial omics technologies to better understand the immune and spatial structures within the livers of patients with various liver conditions, including fatty liver, hepatic hemangioma, focal nodular hyperplasia, liver fibrosis, cirrhosis, and hepatitis B virus HBV infection. Researchers seek to uncover the mechanisms behind liver degeneration during aging and disease progression, as well as to identify molecular features and cellular networks at different stages to find potential new targets for treatment. Participants include patients across different age groups and disease severities who are undergoing hepatectomy or liver biopsy. The study collects preoperative peripheral blood samples and discarded liver tissue during surgery or biopsy. No experimental treatments are given instead, clinical care continues as usual. The study groups are divided based on age, fatty liver severity, liver fibrosis stage, and HBV infection status to analyze differences in liver degeneration and regeneration. During participation, researchers gather demographic data, medical history, physical exam findings, and biological samples including 30 milliliters of peripheral blood and liver tissue discarded during surgery. The study monitors liver inflammation changes immediately after surgery and evaluates hepatocyte aging scores. No additional visits beyond routine care are required. Safety is monitored through reporting adverse events, including serious events such as hospitalization or life-threatening conditions. The total participation duration varies depending on clinical care schedules.

Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease