Actively Recruiting
Single Cell Sequencing to Examine the Pathogenesis of Adenotonsillar Hypertrophy in Children With Obstructive Sleep Apnoea
Led by Chinese University of Hong Kong · Updated on 2025-02-13
15
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA) in children is a common sleep disorder marked by repeated blockage of the upper airway during sleep. It is linked to various health problems affecting multiple organs. Adenotonsillar hypertrophy, or enlarged tonsils and adenoids, is the most frequent cause of OSA in children, but why some children develop this enlargement while others do not is not well understood. This research aims to study the specific cell types and immune involvement in adenotonsillar hypertrophy using single-cell sequencing to better understand how this condition develops in children with OSA. Children aged 6 to 11 years with habitual snoring and confirmed OSA who have enlarged tonsils and adenoids and need surgery to remove them will be included as cases. Children without OSA who undergo surgery for other reasons like recurrent tonsillitis will serve as controls. The tonsil and adenoid tissues from all participants will be collected during surgery and analyzed with single-cell sequencing to identify differences in cell characteristics. Participants will undergo polysomnography to confirm OSA status and have adenotonsillectomy if clinically indicated. The main focus is to study the cell features in tonsillar tissue over about two years. This study involves collecting tissue samples during surgery, followed by detailed laboratory analysis to investigate the disease mechanisms. No additional treatments or long-term follow-up beyond sample analysis are described.
CONDITIONS
Brief Title
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chinese children aged 6 to 11 years old
- Habitual snoring at least 3 nights per week
- Polysomnography confirmed obstructive sleep apnea with an obstructive apnea hypopnea index of 1 or more per hour
- Presence of adenotonsillar hypertrophy with clinical indication for adenotonsillectomy (for cases)
- Non-OSA subjects with obstructive apnea hypopnea index less than 1 per hour undergoing adenotonsillectomy for other reasons such as recurrent tonsillitis (for controls)
You will not qualify if you...
- Previous upper airway surgery
- Genetic or syndromal disease
- Congenital or acquired neuromuscular disease
- Congenital or acquired immunodeficiency
- Known metabolic syndrome
- Craniofacial abnormalities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants who are diagnosed with obstructive sleep apnea and adenotonsillar hypertrophy or non-OSA subjects undergoing adenotonsillectomy for other reasons will undergo adenotonsillectomy to obtain tissue for analysis.
1 visit (in-person)
Duration - Up to 2 years
Participants will be followed for up to 2 years to monitor tonsil cell characteristics after surgery.
Follow-up visits as needed
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
K
Kate C Chan, MBChB
E
Elly Cheung
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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