Actively Recruiting
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Led by Chinese University of Hong Kong · Updated on 2025-02-13
15
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep. It is an important disease as it is associated with a large spectrum of end-organ morbidities. Adenotonsillar hypertrophy is the commonest cause of OSA in children, however, the cause of the lymphoid tissue hypertrophy in some individuals but not the others remains unknown. To address the cellular heterogeneity and immune cell involvement in adenotonsillar hypertrophy, here, we propose to employ single-cell sequencing analysis to identify the cell-specific expression patterns associated with the disease, which will enhance our understanding of the pathogenesis of tonsillar hypertrophy in children with OSA and may provide directions for development of novel therapy.
CONDITIONS
Official Title
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chinese children aged 6 to 11 years
- Habitual snoring at least 3 nights per week
- Polysomnography confirmed obstructive sleep apnea with an obstructive apnea hypopnea index of 1 or more per hour
- Adenotonsillar hypertrophy with clinical indication for adenotonsillectomy
- Non-OSA children with apnea hypopnea index less than 1 per hour undergoing adenotonsillectomy for other reasons such as recurrent tonsillitis
You will not qualify if you...
- Previous upper airway surgery
- Genetic or syndromal diseases
- Congenital or acquired neuromuscular diseases
- Congenital or acquired immunodeficiency
- Known metabolic syndrome
- Craniofacial abnormalities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
K
Kate C Chan, MBChB
CONTACT
E
Elly Cheung
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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