Actively Recruiting
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
Led by Centre Hospitalier Universitaire Dijon · Updated on 2024-06-07
66
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.
CONDITIONS
Official Title
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Person who has given written consent
- Adult (18 years or older)
- Fasting for more than 2 hours before gustatory evoked potential measurement
- Body Mass Index (BMI) less than 30 kg/m²
- For healthy volunteers: enrolled in the national register of healthy volunteers, no cognitive complaints, and normal neurological assessment
- For idiopathic Parkinson's disease patients: meet diagnostic criteria for established or probable IPD
- For Lewy body disease patients: meet diagnostic criteria for probable or possible LBD
You will not qualify if you...
- Not affiliated with national health insurance
- Under legal protection such as curatorship or guardianship
- Subject to a court order
- Pregnant, parturient, or breastfeeding women
- Unable to give consent
- MMSE score less than 15 and/or MoCA score less than 10
- Known COVID-19 infection within 6 months prior to inclusion
- Active smoker of more than 4 cigarettes per day regularly
- Having a pacemaker (contraindicated for bioelectrical impedance analysis)
- Diagnosed with type 1 or type 2 diabetes
- Taking medications that interfere with taste at the time of the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chu Dijon Bourgogne
Dijon, France
Actively Recruiting
Research Team
V
Vincent SCHNEIDER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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