Actively Recruiting
Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma
Led by National University Hospital, Singapore · Updated on 2025-04-04
100
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
Sponsors
N
National University Hospital, Singapore
Lead Sponsor
N
National University of Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
Single centre prospective evaluation of 68Gallium(Ga68)-FAPI-46 PET/MRI in patients diagnosed with Hepatocellular Carcinoma (HCC). 68Gallium-FAPI-46 PET/MRI and standard contrasted multiphasic MRI imaging will be acquired in patients with radiological or histological diagnosis of HCC. The PET scan results will be compared to standard imaging to evaluate its role in lesion detection, characterisation and staging in patients with HCC.
CONDITIONS
Official Title
Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21-99 years
- Diagnosis of Hepatocellular Carcinoma based on histological assessment or radiological criteria per American Association for the Study of Liver Diseases guidelines
- No prior locoregional therapy for Hepatocellular Carcinoma
- Creatinine clearance greater than 30 ml/min based on Cockcroft Gault formula
- Able to provide informed signed consent
You will not qualify if you...
- Allergy to 68Gallium-FAPI contrast agents
- Contraindication to MRI, including MRI incompatible metallic implants, cardiac pacemaker, or claustrophobia
- Weight greater than 150 kg
- Known active malignancy other than Hepatocellular Carcinoma
- Hepatic surgery within the last 30 days
- Active inflammatory conditions affecting FAPI imaging, such as active infection, IgG4-related disease, or inflammatory bowel disease
- Pregnancy; women of childbearing age must have a negative urine pregnancy test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Robert John Walsh
Singapore, Singapore, 119074
Actively Recruiting
Research Team
R
Robert Walsh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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