Actively Recruiting
A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement.
Led by Queen Mary University of London · Updated on 2026-01-07
50
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main goal of this study is to see if a wearable device can reliably track changes in lactate levels in the body. We\'ll compare the device\'s readings to standard blood tests to ensure accuracy. If successful, this device could reduce the need for frequent blood tests during surgery recovery, making patients more comfortable. It might also be useful in emergency rooms for quick diagnoses, especially for patients with chest pain. This study will take place at Barts Hospital with patients having planned coronary artery bypass graft (CABG) and/or replacement valve surgery. Participants will wear the sensors on their upper arm, during which the sensors will continuously measure lactate levels. Participants will also have hourly blood samples taken. In the future, the data from this new device will be used to train computer algorithms to provide quick responses that help manage a patient\'s condition, improving future medical care and technology.
CONDITIONS
Official Title
A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able and willing to give informed consent
- Age between 18 and 90 years old
- Successful coronary artery bypass graft and/or valve insertion surgery without major complications such as significant bleeding requiring reoperation or major stroke
You will not qualify if you...
- Previous coronary artery bypass graft surgery
- Acute coronary syndrome within 4 weeks before consent
- Heart failure with ejection fraction less than 35%
- Chronic severe kidney failure with eGFR less than 30 mL/min/1.73m2
- Severe anemia with hemoglobin less than 10
- Known or suspected allergy to medical grade silicone adhesives
- Pre-existing skin conditions, burns, open wounds, or significant lesions on the upper arm
- Implanted medical devices such as pacemakers or other cardiac devices
- Severe liver cirrhosis stage III or higher
- Lymphoedema or pitting edema at time of consent
- Pregnancy
- History of ongoing malignant disease
- Low albumin levels less than 35 g/L
- Lack of capacity to consent or vulnerable adults
- Unable to speak English
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Barts Health
London, United Kingdom
Actively Recruiting
Research Team
P
Prof Anthony Mathur
CONTACT
E
Emily Kirkpatrick
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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