Actively Recruiting
Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Led by McMaster University · Updated on 2026-01-07
3254
Participants Needed
25
Research Sites
336 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
H
Hamilton Health Sciences Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.
CONDITIONS
Official Title
Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant people aged 18 to 55 years at risk of preterm birth with singleton or twin pregnancy between 22 weeks 0 days and less than 34 weeks 6 days gestation
- Have received only a single dose of Celestone within the past 24 hours
- Able to provide informed, written consent
You will not qualify if you...
- Contraindication to corticosteroids
- Use of systemic corticosteroids for medical conditions during pregnancy (e.g., lupus, severe asthma, Covid)
- Previous participation in this trial during an earlier pregnancy
- Known severe or life-threatening condition in the fetus or pregnant person (e.g., fetal congenital or chromosomal abnormalities)
- Death of one or more fetuses after 14 weeks 0 days gestation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
University of Calgary, Cumming School of Medicine
Calgary, Alberta, Canada
Actively Recruiting
2
Alberta Health Services; University of Alberta
Edmonton, Alberta, Canada
Actively Recruiting
3
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Not Yet Recruiting
4
Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre
Surrey, British Columbia, Canada
Not Yet Recruiting
5
University of British Columbia; BC Women's Hospital
Vancouver, British Columbia, Canada
Not Yet Recruiting
6
Victoria General Hospital
Victoria, British Columbia, Canada
Not Yet Recruiting
7
University of Manitoba, Health Sciences Centre
Winnipeg, Manitoba, Canada
Not Yet Recruiting
8
University of Manitoba; St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Not Yet Recruiting
9
Dr. Everett Chalmers Regional Hospital
Fredericton, New Brunswick, Canada
Actively Recruiting
10
The Moncton Hospital, Horizon Health Network
Moncton, New Brunswick, Canada
Actively Recruiting
11
Memorial University, Eastern Health
St. John's, Newfoundland and Labrador, Canada
Not Yet Recruiting
12
Dalhousie University; Izaak Walton Killam Health
Halifax, Nova Scotia, Canada
Actively Recruiting
13
McMaster University
Hamilton, Ontario, Canada
Actively Recruiting
14
Queen's University, Kingston General Hospital Health Sciences Centre
Kingston, Ontario, Canada
Actively Recruiting
15
Western University; London Health Sciences Centre, Victoria Hospital
London, Ontario, Canada
Actively Recruiting
16
University of Ottawa; The Ottawa Hospital
Ottawa, Ontario, Canada
Actively Recruiting
17
Mount Sinai Hospital
Toronto, Ontario, Canada
Actively Recruiting
18
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada
Actively Recruiting
19
Hopital Maisonneuve Rosemont, CIUSSS de l'est de l'Ile de Montréal
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
20
McGill University, McGill University Health Center, Royal Victoria Hospital
Montreal, Quebec, Canada
Actively Recruiting
21
Sir Mortimer B. Davis Jewish General Hospital; McGill University
Montreal, Quebec, Canada
Not Yet Recruiting
22
The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal
Montreal, Quebec, Canada
Actively Recruiting
23
Université Laval, Centre de recherche du CHU de Québec
Québec, Quebec, Canada
Actively Recruiting
24
(CIUSSS de l'Estrie-CHUS); Université de Sherbrooke
Sherbrooke, Quebec, Canada
Actively Recruiting
25
University of Saskatchewan, Regina General Hospital
Saskatoon, Saskatchewan, Canada
Not Yet Recruiting
Research Team
S
Sarah D McDonald, MD,MSc,FRCSC
CONTACT
S
SNACS Coordinating Centre
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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