Actively Recruiting
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia
Led by Makerere University · Updated on 2026-04-28
356
Participants Needed
1
Research Sites
423 weeks
Total Duration
On this page
Sponsors
M
Makerere University
Lead Sponsor
U
University of Minnesota
Collaborating Sponsor
AI-Summary
What this Trial Is About
This will be a randomized controlled trial of asymptomatic (Cryptococcal Antigen test)CrAg positive persons in Uganda. Patients will be randomized to receive preemptive treatment with 1 dose of liposomal amphotericin (10mg/kg) in addition to standard of care fluconazole therapy. How the enhanced antifungal therapy prevents progression to meningitis in the first 24-weeks and overall survival in those who receive the intervention compared with participants receiving fluconazole per World Health Organisation (WHO) and national standard of care therapy will be evaluated.
CONDITIONS
Official Title
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- HIV-1 infection
- Age 15 years or older
- Ability and willingness to give informed consent
- Plasma or serum cryptococcal antigen (CrAg) positive with a titer of 1:160 or greater
You will not qualify if you...
- Cannot or unlikely to attend regular clinic visits
- History of cryptococcal infection
- Symptomatic meningitis confirmed by cerebrospinal fluid CrAg positive
- More than 14 days of fluconazole therapy
- Pregnancy confirmed by urinary or serum pregnancy test
- Current breastfeeding
- Known allergy to amphotericin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
infectious Disease Institute Kampala,Uganda
Kampala, Uganda
Actively Recruiting
Research Team
D
DAVID MEYA, PhD
CONTACT
E
ELIZABETH NALINTYA, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here