Actively Recruiting
Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness
Led by Ankara City Hospital Bilkent · Updated on 2026-01-07
102
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with a rising incidence particularly in high-income countries. Although often life-saving, cesarean delivery carries both short- and long-term maternal risks. Early complications include infection, hemorrhage, and thromboembolism, while inadequate uterine healing can lead to future complications such as uterine rupture and placenta accreta spectrum disorders. Additionally, cesarean scars may result in pregnancy complications, isthmocele formation, postmenstrual bleeding, pelvic pain, and dysmenorrhea. This highlights the need for optimization of the surgical technique. Despite increasing cesarean rates, there is no consensus on the optimal uterine closure method. Techniques vary in terms of the number of layers, suture locking style, and inclusion of the endometrium, and their comparative effectiveness in reducing scar defects remains unclear. Some previous studies have reported increased uterine rupture risk with single-layer locked sutures and better healing with double-layer closure, while others found no significant difference in scar outcomes. This study aims to investigate the effects of single- versus double-layer cesarean scar closure on myometrial thickness and its clinical implications.
CONDITIONS
Official Title
Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 18-44 years
- Scheduled for cesarean delivery at the study hospital's Obstetrics and Gynecology clinic
- Clinically eligible based on history, physical examination, abdominal ultrasound, and routine preoperative lab tests including CBC, biochemical profile, PT, aPTT, and blood group determination with no abnormalities detected
You will not qualify if you...
- Presence of chronic diseases such as rheumatologic diseases, renal failure, vascular malformations, hypertension, cardiac disease, diabetes mellitus, obesity, thyroid disease, or congenital hematologic disorders
- Suspected or confirmed placenta previa or placenta accreta spectrum
- Clinical chorioamnionitis
- Anterior wall uterine myomas
- History of low transverse nonstandard uterine incision
- Predicted obstetric hemorrhage or other intraoperative complications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Not Valid, Turkey (Türkiye), 06100
Actively Recruiting
Research Team
M
Merve Didem Eşkin Tanrıverdi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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