Actively Recruiting

Phase Not Applicable
Age: 18Years - 44Years
FEMALE
Healthy Volunteers
NCT07323355

Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness

Led by Ankara City Hospital Bilkent · Updated on 2026-01-07

102

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with a rising incidence particularly in high-income countries. Although often life-saving, cesarean delivery carries both short- and long-term maternal risks. Early complications include infection, hemorrhage, and thromboembolism, while inadequate uterine healing can lead to future complications such as uterine rupture and placenta accreta spectrum disorders. Additionally, cesarean scars may result in pregnancy complications, isthmocele formation, postmenstrual bleeding, pelvic pain, and dysmenorrhea. This highlights the need for optimization of the surgical technique. Despite increasing cesarean rates, there is no consensus on the optimal uterine closure method. Techniques vary in terms of the number of layers, suture locking style, and inclusion of the endometrium, and their comparative effectiveness in reducing scar defects remains unclear. Some previous studies have reported increased uterine rupture risk with single-layer locked sutures and better healing with double-layer closure, while others found no significant difference in scar outcomes. This study aims to investigate the effects of single- versus double-layer cesarean scar closure on myometrial thickness and its clinical implications.

CONDITIONS

Official Title

Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness

Who Can Participate

Age: 18Years - 44Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Female participants aged 18-44 years
  • Scheduled for cesarean delivery at the study hospital's Obstetrics and Gynecology clinic
  • Clinically eligible based on history, physical examination, abdominal ultrasound, and routine preoperative lab tests including CBC, biochemical profile, PT, aPTT, and blood group determination with no abnormalities detected
Not Eligible

You will not qualify if you...

  • Presence of chronic diseases such as rheumatologic diseases, renal failure, vascular malformations, hypertension, cardiac disease, diabetes mellitus, obesity, thyroid disease, or congenital hematologic disorders
  • Suspected or confirmed placenta previa or placenta accreta spectrum
  • Clinical chorioamnionitis
  • Anterior wall uterine myomas
  • History of low transverse nonstandard uterine incision
  • Predicted obstetric hemorrhage or other intraoperative complications

AI-Screening

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Trial Site Locations

Total: 1 location

1

Ankara Bilkent City Hospital

Ankara, Not Valid, Turkey (Türkiye), 06100

Actively Recruiting

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Research Team

M

Merve Didem Eşkin Tanrıverdi, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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