Actively Recruiting
Single-isocenter SBRT vs. Multiple-isocenter SBRT for Multiple Extracranial Metastases
Led by Matthias Guckenberger · Updated on 2024-03-13
62
Participants Needed
1
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized non-inferiority clinical trial is to investigate whether single-isocenter SBRT using one treatment plan is similarly effective as multiple-isocenter SBRT using multiple treatment plans for multiple extracranial metastases. The main question it aims to answer is: \- whether 1-year freedom from local disease progression at the site of treated metastases after single-isocenter SBRT is non-inferior against multiple-isocenter SBRT at the same prescription doses. Cancer patients with multiple extracranial distant metastases will be randomly assigned and treated either with single-isocenter SBRT or multiple-isocenter SBRT.
CONDITIONS
Official Title
Single-isocenter SBRT vs. Multiple-isocenter SBRT for Multiple Extracranial Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent before any study procedures
- Diagnosed distant extracranial metastases from confirmed cancer
- Metastases confirmed by imaging including CT, MRI (for spine/liver), or PET/CT (if applicable)
- At least 2 distant metastases suitable for single-isocenter treatment as determined by the clinician
- Willing and able to comply with visits, treatments, and study procedures
You will not qualify if you...
- Previous radiotherapy for distant metastases causing overlapping treatment areas with excessive dose
- Metastases extending into gastrointestinal tract or skin
- Large distance between metastases or metastases in different organs with different motion patterns
- Pregnant or breastfeeding women
- Intending to become pregnant during the study
- Lack of safe contraception for women of childbearing potential
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow study procedures due to language or other issues
- Investigator or related persons enrolled in the study
- Women post-hysterectomy, bilateral oophorectomy, or postmenopausal for over 2 years are not considered of childbearing potential
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Radiation Oncology, University Hospital Zurich
Zurich, Switzerland, 8091
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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