Ultrasound-guided brachial and basilic vein cannulation in emergency department patients with difficult intravenous access.
L E Keyes, B W Frazee, E R Snoey...
https://pubmed.ncbi.nlm.nih.gov/10577399/Actively Recruiting
Led by Albany Medical College · Updated on 2026-01-20
270
Participants Needed
1
Research Sites
52 weeks
Total Duration
This research aims to compare two types of intravenous catheters used in emergency department patients who have veins that are difficult to access for intravenous IV treatment. The study focuses on comparing a 10-centimeter single lumen midline catheter with a 4.78-centimeter long peripheral IV catheter to see which device stays functional longer and has fewer complications. Difficult IV access can delay treatment, so finding the better catheter could improve care delivery for these patients. Participants will be randomly assigned to receive either the long peripheral IV catheter or the midline catheter. Both devices are inserted using ultrasound guidance to visualize veins and ensure proper placement. The midline catheter uses a guidewire technique to assist insertion, while the long peripheral IV does not. The study devices are standard care and approved for use. Insertion is performed by trained clinicians in the emergency department, and detailed ultrasound images will be taken during placement. During the study, participants will be followed from the time of catheter placement through up to 28 days after removal. Researchers will collect data on catheter dwell time, complications, and patient and provider satisfaction using surveys and medical records. Arm measurements, catheter position, and time taken for device placement will also be recorded. Participants will be monitored daily while hospitalized and contacted after discharge to assess outcomes and any issues related to catheter use.
CONDITIONS
Single Lumen Midline Catheter vs Long Peripheral Intravenous Cather for Difficult Intravenous Access in the ED
A
Alexander Bracey, MD
M
Michael J Waxman, MD
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Albany Medical College
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | 10-cm Single Lumen Midline Catheter | 4.78-cm Long Peripheral IV Catheter |
|---|---|---|
| What it is | A 10-cm single lumen midline catheter (BD Powerglide Pro) designed for vascular access when standard IV placement is difficult. Inserted using ultrasound guidance without the need for chest X-ray confirmation. | A 4.78-cm long peripheral intravenous catheter (BD Insyte Autoguard), used for IV access in patients with difficult veins. Also inserted under ultrasound guidance. |
| Role in trial | Investigational arm being evaluated for effectiveness and safety in emergency department patients with difficult intravenous access. | Active comparator arm representing the standard long peripheral IV approach in challenging access cases. |
| Primary use | Used to achieve reliable IV access in adults with difficult veins when standard IV attempts have failed. | Provides peripheral IV access for difficult cases, typically after failed standard catheter attempts. |
| How it is given or performed | Inserted under ultrasound guidance by trained staff using sterile technique; does not require catheter measurement/trimming or chest X-ray for use. | Placed under ultrasound guidance with standard aseptic protocol; device is pre-sized, self-retracting, and requires no trimming. |
| Evidence status | There is increasing published evidence on the safety and dwell time of midline catheters in difficult IV access populations, but large randomized trials are limited. | Long peripheral IV catheters are supported by randomized studies for improving catheter survival in ultrasound-guided placement compared to standard-length catheters. |
| Important limitations | Potential for complications such as thrombosis, infection, or device malfunction as reported in systematic reviews; generalizability limited by single-institution data. | While long peripheral IVs improve survival compared to standard catheters, they may still fail or infiltrate, and effectiveness can depend on operator experience. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) in the emergency department for screening and enrollment
Duration - Single visit lasting up to 2 hours
Participants receive placement of either a 10-cm single lumen midline catheter or a 4.78-cm long peripheral intravenous catheter using ultrasound guidance in the emergency department. The catheter is inserted using sterile technique by trained clinicians, with ultrasound images captured for vessel assessment. Blood samples may be drawn and the catheter flushed and secured after placement.
1 visit (in-person) in the emergency department for catheter placement
Duration - Up to 28 days following catheter placement and until catheter removal
Participants are monitored daily during their hospital stay for catheter function and complications such as displacement, infiltration, infection, or occlusion. Study personnel visit participants daily to assess the catheter site and record any issues. Additional IV placements or catheter removals are managed per clinical care.
Daily visits in hospital for up to 28 days or until catheter removal
Duration - 1 month after catheter removal
After catheter removal or hospital discharge, participants are contacted by phone at 1 month to assess for any complications related to the catheter placement and use. Chart reviews are also performed at 1 week and 28 days post-removal to collect outcome data.
Phone call(s) for follow-up assessments
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/21703801/Albany Medical College
Lead Sponsor