Actively Recruiting
A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults
Led by Scholar Rock, Inc. · Updated on 2026-03-02
76
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A phase 1 study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of SRK-439 in healthy adults
CONDITIONS
Official Title
A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants aged 18 to 55 years at the time of consent
- Body mass index (BMI) between 18 and 35 kg/m2 at screening
You will not qualify if you...
- Prior treatment with SRK-439, apitegromab, or other anti-myostatin therapies including ACTR antagonists
- History of immunosuppressive, chemotherapy, or radiation treatment within 12 months before screening
- Current or past use of anabolic steroids, growth hormones, or other muscle-influencing substances
- Use of therapies with significant muscle effects (eg, insulin-like growth factor, systemic beta-agonists, neurotoxins, muscle relaxants, or muscle-enhancing supplements) within 3 months before screening or during the study
- History of exposure to monoclonal antibodies or Fc domain recombinant proteins within 5 years with hypersensitivity reactions
- Treatment with investigational drugs or biologic therapeutics within 3 months or 5 half-lives before screening, whichever is longer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medpace CPU
Cincinnati, Ohio, United States, 45227
Actively Recruiting
Research Team
S
Scholar Rock, Inc. Clinical Trials Administration
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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