Actively Recruiting
Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)
Led by 424 General Military Hospital · Updated on 2025-04-27
125
Participants Needed
9
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A 24-month prospective, open-label, randomized, multicenter, multinational, non-inferiority pragmatic clinical trial evaluating zoledronate single or double infusion versus oral alendronate following denosumab
CONDITIONS
Official Title
Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal women treated with denosumab for 3 or more years who will reach osteopenia
You will not qualify if you...
- Bone disease other than postmenopausal osteoporosis
- Use of medications other than bisphosphonates or SERMS affecting bone metabolism during the last 12 months before entering the study
- Creatinine clearance less than 60 mL/min/1.73 m2
- Liver failure
- Any type of cancer
- Uncontrolled endocrine diseases
- Serum 25-hydroxy vitamin D concentrations lower than 20 ng/mL (50 nmol/L)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Univ. Lille, CHU Lille
Lille, France
Actively Recruiting
2
251 Hellenic Airforce and VA General Hospital
Athens, Greece, 11525
Actively Recruiting
3
First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens
Athens, Greece, 11527
Actively Recruiting
4
, KAT General Hospital
Athens, Greece, 14561
Actively Recruiting
5
424 General Military Hospital
Thessaloniki, Greece, 56429
Actively Recruiting
6
Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico
Milan, Italy
Not Yet Recruiting
7
Campus Bio-Medico University
Roma, Italy, 00128
Not Yet Recruiting
8
Department of Medicine, Surgery and Neurosciences, University of Siena
Siena, Italy, 53100
Not Yet Recruiting
9
University-Hospital S. Maria della Misericordia
Udine, Italy
Not Yet Recruiting
Research Team
A
Athanasios D Anastasilakis, MD
CONTACT
J
John Carey, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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