Actively Recruiting
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
Led by Ondokuz Mayıs University · Updated on 2026-04-06
52
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.
CONDITIONS
Official Title
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- ASA (American Society of Anesthesiologists) physical status II to IV
- Undergoing elective cardiac surgery including coronary artery bypass grafting, mitral valve replacement, or aortic valve replacement
You will not qualify if you...
- Emergency surgery
- Presence of perioperative arrhythmia
- Left ventricular ejection fraction less than 35%
- Systolic pulmonary artery pressure greater than 50 mmHg
- Known chronic obstructive pulmonary disease or interstitial lung disease
- Pneumothorax
- Mean arterial pressure less than 60 mmHg during recruitment maneuver
- New York Heart Association class III or IV heart failure
- Advanced cardiomyopathy or severe mitral regurgitation
- Cross-clamp time longer than 2 hours
- Requirement for high-dose inotropic or vasopressor support
- Inability to be extubated within 24 hours after surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ondokuz Mayıs University, Faculty of Medicine
Samsun, Atakum, Turkey (Türkiye), 55270
Actively Recruiting
Research Team
B
Burhan Dost, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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