Lung recruitment maneuver depresses central hemodynamics in patients following cardiac surgery.
Jonas Nielsen, Morten Østergaard, Jesper Kjaergaard...
https://pubmed.ncbi.nlm.nih.gov/16096751/Actively Recruiting
Led by Ondokuz Mayıs University · Updated on 2026-07-01
52
Participants Needed
1
Research Sites
12 weeks
Total Duration
Researchers are evaluating two different lung recruitment methods in adults undergoing planned heart surgery with cardiopulmonary bypass to see how each affects heart function and lung health. The trial focuses on comparing a single-step sustained inflation maneuver and a stepwise incremental maneuver, both used after the heart-lung machine is stopped. This study aims to find the best approach to improve lung function while keeping the heart stable during recovery after surgery. Participants will receive one of two lung recruitment maneuvers after separation from cardiopulmonary bypass either a single-step sustained inflation at 30 cmH2O for 30 seconds or a stepwise maneuver increasing airway pressure by 5 cmH2O every 5 seconds up to 30 cmH2O, then decreasing similarly. Both methods are combined with continuous positive pressure of 8 cmH2O to keep the lungs open. This randomized trial compares these two procedures to assess their effects on heart and lung function. During the study, participants will have hemodynamic measurements, including cardiac index, heart rate, blood pressure, and lung ultrasound atelectasis scores taken before and after the recruitment maneuvers and on the first day after surgery. Additional assessments include blood gas analysis and lung mechanics. Researchers will also monitor recovery markers such as extubation time and ICU stay length. The total involvement covers the intraoperative period through postoperative day one, focusing on safety and effectiveness of the lung recruitment strategies.
CONDITIONS
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
B
Burhan Dost, MD
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Ondokuz Mayıs University
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - During surgery after separation from cardiopulmonary bypass
Participants receive either a single-step sustained inflation lung recruitment maneuver or a stepwise incremental recruitment maneuver after cardiopulmonary bypass, both combined with positive end-expiratory pressure.
Duration - Up to 1 day after surgery
Heart and lung function are monitored using ultrasound, blood tests, and hemodynamic measurements during surgery and on the first day after surgery.
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Jonas Nielsen, Morten Østergaard, Jesper Kjaergaard...
https://pubmed.ncbi.nlm.nih.gov/16096751/Serdar Celebi, Ozge Köner, Ferdi Menda...
https://pubmed.ncbi.nlm.nih.gov/17242096/Sheila N Myatra
https://pubmed.ncbi.nlm.nih.gov/31920224/Silvia Mongodi, Andrea Cortegiani, Almudena Alonso-Ojembarrena...
https://pubmed.ncbi.nlm.nih.gov/40353867/Silvina Longo, Juan Siri, Cecilia Acosta...
https://pubmed.ncbi.nlm.nih.gov/27861261/Ondokuz Mayıs University
Lead Sponsor