Actively Recruiting
Single-tracer Multiparametric PET Imaging
Led by University of California, Davis · Updated on 2026-03-10
60
Participants Needed
1
Research Sites
493 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
N
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that quantitative blood flow can be extracted from dynamic 18F-FDG PET data by use of tracer kinetic modeling, in addition to glucose metabolism that 18F-FDG is conventionally used for.
CONDITIONS
Official Title
Single-tracer Multiparametric PET Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Ability to understand and sign informed consent
- Willingness and ability to follow the study schedule and requirements
- Willing to fast for at least 6 hours before and during the scan
- No strenuous exercise for 24 hours before scanning
- Willing to lie still on the scanner bed for up to 60 minutes
- No active COVID-19 symptoms
- Healthy volunteers must have no history of cardiovascular, inflammatory, infectious, or metabolic diseases affecting tissue perfusion or metabolism
- Patients may have acute or chronic cardiovascular, cardiometabolic, or cardiopulmonary diseases such as ischemic heart disease, myocarditis, arrhythmias, heart failure, nonalcoholic fatty liver disease, COVID-related sequela, diabetes, hypertension, or renal disease that affect tissue perfusion or metabolism
You will not qualify if you...
- History of anxiety or discomfort in closed spaces
- Body weight over 240 kg
- Pregnant or breastfeeding women
- Blood glucose over 200 before 18F-FDG injection
- Participation in another PET research study within the past 12 months
- Prisoners
- Any condition preventing informed consent
- Any comorbidity that may interfere with study objectives as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UC Davis EXPLORER Molecular Imaging Center
Sacramento, California, United States, 95816
Actively Recruiting
Research Team
C
Clinical Research Team
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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