Actively Recruiting
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Led by Indiana University · Updated on 2025-12-16
64
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
A
American Rhinologic Society
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
CONDITIONS
Official Title
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Diagnosed with cystic fibrosis and currently on highly effective modulator therapy (HEMT)
- History of chronic rhinosinusitis
- Using topical nasal irrigations with or without steroids or antibiotics
You will not qualify if you...
- Under 18 years old
- Cystic fibrosis patients not on highly effective modulator therapy
- Pregnant patients
- Not currently using topical nasal irrigations with or without steroids or antibiotics
- History of sinonasal or nasopharyngeal tumors
- Active sinonasal or pulmonary infection
- Hospital admission for pulmonary exacerbation within the last 3 months
- Use of oral antibiotics within the last month for respiratory infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Indiana University Health
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
E
Elisa Illing, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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