Actively Recruiting
Sitting Interruption and Whole-body Cardiovascular Health
Led by University of North Carolina, Chapel Hill · Updated on 2026-03-16
56
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.
CONDITIONS
Official Title
Sitting Interruption and Whole-body Cardiovascular Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 30-60 years
- Exercise less than 90 minutes per week for the past 3 months
- Sit for more than 8 hours per day
- Able to walk 4 blocks and climb 2 flights of stairs
- Own a cell phone able to receive text messages
You will not qualify if you...
- Use of assisted-walking devices
- Medical conditions limiting ability to reduce sitting (e.g., musculoskeletal issues, current chemotherapy)
- Plans for major surgery within next 3 months
- History within last year of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
- Recent or planned bariatric surgery
- High blood pressure (systolic 60 mmHg or diastolic 100 mmHg)
- Current or recent pregnancy or breastfeeding
- Morbid obesity (BMI over 40) or underweight (BMI under 18.5)
- Use of anti-hypertensive or glucose-controlling medications
- Heavy alcohol use (more than 15 drinks per week)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
E
Erik Hanson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
4
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