Actively Recruiting
Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk
Led by Creighton University · Updated on 2024-09-25
80
Participants Needed
1
Research Sites
289 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics. The bone density of people with Type 1 Diabetes is higher at the time of fracture than in non-diabetics. This suggests the presence of underlying bone tissue mechanical defects. The potential benefits to participants would be knowledge gained about their bone density and the results of laboratory tests. On a wider scale, there may be general benefits to society because the knowledge gained from this study may help better understand the effects of diabetes on bone health
CONDITIONS
Official Title
Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients with Type 1 Diabetes Mellitus
- Age 50 years or older
- Postmenopausal for at least 5 years
- Have had diabetes for more than 10 years
- No chronic diseases affecting bone as confirmed by the investigator
- Normal clinical history, physical exam, and laboratory results except for typical mild diabetic complications
- Glomerular Filtration Rate (GFR) greater than 45 ml/min
- Willing to sign consent and undergo transiliac bone biopsy
- Caucasian
- For non-diabetic controls: matched to diabetic participant within +/- 15% hip bone density, +/- 10% BMI, and +/- 5 years age
- Caucasian
You will not qualify if you...
- Women with Type 1 Diabetes for less than 10 years
- Non-insulin dependent Type 1 Diabetes
- Younger than 50 years old
- Less than 5 years postmenopausal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Creighton University Osteoporosis Research Center
Omaha, Nebraska, United States, 68122
Actively Recruiting
Research Team
A
Adam Hornig
CONTACT
L
Laura Armas, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here