Actively Recruiting
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
Led by Massachusetts General Hospital · Updated on 2025-10-30
36
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
C
Cystic Fibrosis Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with diagnosed with CF exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including glycemic control, inflammation, and bone turnover markers.
CONDITIONS
Official Title
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 13 to 20 years old
- Diagnosed with cystic fibrosis and pancreatic insufficiency
- Stable treatment regimen, including CFTR modulator use unchanged for the prior three months
- Liver transplant recipients eligible if at least 1 year post-transplant and no longer on Prednisone for immunosuppressive therapy
You will not qualify if you...
- Diagnosis of other chronic diseases affecting bone health
- Active use of medications known to affect skeletal metabolism within the past 3 months
- CF exacerbation or glucocorticoid exposure within the prior 1 month
- Lung transplant recipients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
R
Rebecca Gordon, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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