Actively Recruiting
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Led by Massachusetts General Hospital · Updated on 2025-10-30
92
Participants Needed
1
Research Sites
324 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
CONDITIONS
Official Title
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control
You will not qualify if you...
- Chronic disease known to affect skeletal metabolism
- Use of medications within prior 3 months known to affect skeletal metabolism
- Pregnancy
- History of claustrophobia, incompatible internal metal, or abnormality on or near the left knee
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
R
Rebecca Gordon, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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