Actively Recruiting
Skeletal Muscle Aging and Responsiveness in Aged People With MS
Led by Oklahoma Medical Research Foundation · Updated on 2026-03-30
10
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.
CONDITIONS
Official Title
Skeletal Muscle Aging and Responsiveness in Aged People With MS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 60 years or older
- Free of unmanaged chronic diseases other than multiple sclerosis
- No structured exercise program (2 or more sessions per week) within the previous 6 months
- Cognitively capable of providing informed consent
- Expanded Disability Status Scale (EDSS) score between 2 and 5.5 during screening
You will not qualify if you...
- Neuromuscular or musculoskeletal disorders, other than multiple sclerosis, that limit exercise or testing
- Cardiopulmonary disorders or reduced breathing capacity
- Metabolic diseases, including liver disease markers (ALT > 52 U/dl) or type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)
- Taking any dose of metformin
- Diseases influencing exercise response (e.g., chronic kidney disease, Alzheimer's, current cancer diagnosis or remission within 2 years, cerebrovascular disease)
- Chemotherapy history within 5 years
- Use of unchangeable anticoagulants (e.g., Coumadin, Pradaxa)
- Use of insulin sensitizing or metabolic drugs (e.g., metformin, GLP1 agonists)
- Use of high dose statins (40 mg or above)
- Non-correctable visual impairment
- Score less than 29 on the Symbol Digit Test
- Received Botox for spasticity within 3 months prior to participation
- Adjustments to Baclofen medication not allowed during study
- Unable to commit to approximately 4 months of study participation
- Allergy to Lidocaine
- Tobacco use
- Excessive alcohol consumption (3 drinks/day or 7 drinks/week for females; 4 drinks/day or 14 drinks/week for males)
- Body Mass Index (BMI) greater than 35.0 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
Research Team
L
Lena Fuentes
CONTACT
B
Bobbette Miller
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here