Actively Recruiting
Skeletal Muscle Function in Interstitial Lung Disease
Led by University of British Columbia · Updated on 2025-01-16
40
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dyspnea (i.e. breathlessness) and exercise intolerance are common symptoms for patients with interstitial lung disease (ILD), yet it is not known why. It has been suggested that muscle dysfunction may contribute to dyspnea and exercise intolerance in ILD. Our study aims to: i) examine differences in the structure and function of the leg muscles in ILD patients, ii) determine if leg muscle fatigue contributes to dyspnea and exercise limitation in patients with ILD, and iii) determine the effects of breathing extra oxygen on leg muscle fatigue, as well as ability to exercise in ILD patients.
CONDITIONS
Official Title
Skeletal Muscle Function in Interstitial Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 to 80 years inclusive
- Diagnosis of idiopathic pulmonary fibrosis, idiopathic fibrotic nonspecific interstitial pneumonia, chronic hypersensitivity pneumonitis, or unclassifiable ILD with related diagnoses
- Fibrosis visible on high resolution CT scan (honeycombing, reticulation, or traction bronchiectasis)
- Suitable for pulmonary rehabilitation
- Able to walk 50 meters or more in 6 minutes
- Oxygen saturation of 92% or higher at rest on room air
- Clinically stable for at least 6 weeks
- Able to read and write English fluently
- For healthy controls: age 40 to 80 years inclusive
- Normal lung function (80-120% predicted)
- No lung or heart disease
- Able to read and write English fluently
You will not qualify if you...
- Contraindications to exercise testing such as serious heart, muscle, or nerve disease
- Other major diseases that could reduce exercise ability or oxygen levels
- Forced vital capacity less than 50% or carbon monoxide diffusion capacity less than 25%
- Pulmonary rehabilitation program within the last 6 months
- Use of prednisone over 10 mg/day for more than 2 weeks within 3 months before the study
- Significant emphysema (less than 10% volume on CT or FEV1/FVC less than 0.70)
- For healthy controls: current smoking or over 10 pack-years smoking history
- Any medical condition preventing safe exercise
- Presence of a pacemaker or metal/electronic devices inside the body
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z1Y6
Actively Recruiting
Research Team
O
Olivia Ferguson, MSc
CONTACT
S
Satvir S Dhillon, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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