Actively Recruiting
Skeletal Muscle Mitochondria in Ageing
Led by VU University of Amsterdam · Updated on 2024-08-06
60
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Healthy ageing is associated with the loss of muscle mass and physical function. As a result, older people are limited in their independence. The aging of muscles typically begins around the age of 30. From this age onward, muscle strength, muscle mass, and the maximum oxygen uptake of muscles decrease. The reasons for this are not entirely clear, but it seems to be partly related to how oxygen moves from our blood vessels to the muscles and how muscles burn energy. The precise role of age and physical fitness, as well as whether exercise can counteract the effects of ageing, is still unknown. Therefore, in this study, we aim to investigate the muscle function of both physically active and inactive young and middle-aged individuals. We hypothesise that endurance training can mitigate some of the effects of ageing.
CONDITIONS
Official Title
Skeletal Muscle Mitochondria in Ageing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 30 years for young groups or between 50 and 65 years for older groups
- Male or female
- For sedentary groups: not currently engaged in formal exercise training or competitive sports
- For trained groups: currently engaged in formal endurance training at least 3 times per week
- No chronic health conditions likely to affect exercise tolerance or responses
You will not qualify if you...
- Age outside 18-30 years (young groups) or 50-65 years (older groups)
- Unable to provide informed consent
- History of claustrophobia
- Unable to perform the exercise test or follow instructions
- Taking medications that interfere with exercise physiology, such as systemic corticosteroids, statins, SGLT2 inhibitors, or GLP1 receptor agonists
- Contraindications for MRI (e.g., pacemaker, claustrophobia)
- Under investigation for undiagnosed disease
- Body mass index over 30
- Pregnancy
- Current smoker or regular smoker within the past 12 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vrije Universiteit Amsterdam
Amsterdam, North Holland, Netherlands, 1081HV
Actively Recruiting
Research Team
E
Ellen Breedveld, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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